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How to get Nembutal, The barbiturates are nonselective central nervous system depressants which are primarily used as sedative hypnotics and also anticonvulsants in sub hypnotic doses. The barbiturates and their sodium salts are subject to control under the Federal Controlled Substances Act (See “Drug Abuse and Dependence” section).
The sodium salts of am barbital, pentobarbital, phenobarbital, and sec barbital are available as sterile parenteral solutions.
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Barbiturates are substituted pyrimidine derivatives in which the basic structure common to these drugs is barbituric acid, a substance which has no central nervous system (CNS) activity. CNS activity is obtained by substituting alkyl, alkenyl, or aryl groups on the pyrimidine ring.
NEMBUTAL Sodium Solution (pentobarbital sodium injection) is a sterile solution for intravenous or intramuscular injection. Each mL contains pentobarbital sodium 50 mg, in a vehicle of propylene glycol, 40%, alcohol, 10% and water for injection, to volume. The pH is adjusted to approximately 9.5 with hydrochloric acid and/or sodium hydroxide.
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Barbiturate-induced sleep differs from physiological sleep. Sleep laboratory studies have demonstrated that barbiturates reduce the amount of time spent in the rapid eye movement (REM) phase of sleep or dreaming stage. Also, Stages III and IV sleep are decreased. Following abrupt cessation of barbiturates used regularly, patients may experience markedly increased dreaming, nightmares, and/or insomnia. Therefore, withdrawal of a single therapeutic dose over 5 or 6 days has been recommended to lessen the REM rebound and disturbed sleep which contribute to drug withdrawal syndrome (for example, decrease the dose from 3 to 2 doses a day for 1 week).
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Dosages of barbiturates must be individualized with full knowledge of their particular characteristics and recommended rate of administration. Factors of consideration are the patient’s age, weight, and condition. Parenteral routes should be used only when oral administration is impossible or impractical.
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The major uses of Nembutal are as a short-term treatment for insomnia (most often used to help people fall asleep but not as useful in helping people stay asleep), in the treatment of anxiety, as an anticonvulsant in emergency situations, and as a preanesthetic prior to surgery. The drug has also been used to reduce pressure within the skull in cases of traumatic brain injury and as a euthanasia drug for both animals and humans, including use in state executions of criminals. Any drug that can be used to euthanize animals or people is obviously potentially dangerous in high doses.
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